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April 13th, 2011 by dred55

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Men with Erectile Dysfunction Have Increased Risk for Cardiovascular Events

January 27th, 2011 by dred55

Erectile Dysfunction and Heart

Men with erectile dysfunction have a higher risk of subsequent cardiovascular events such as heart attack, stroke, and angina, according to a study in the December 21 issue of JAMA.

More than 10 million men in the United States are affected by erectile dysfunction (ED), with an estimated 100 million men affected worldwide, according to background information in the article. The risk of erectile dysfunction is related to many factors, including age, smoking, diabetes, heart disease, depression, and hypertension. Because cardiovascular disease and erectile dysfunction share etiologies as well as pathophysiology (endothelial dysfunction) and because of evidence that degree of erectile dysfunction correlates with severity of cardiovascular disease, it has been postulated that erectile dysfunction is a sentinel symptom in patients with cardiovascular disease.

Ian M. Thompson, M.D., of the University of Texas Health Science Center at San Antonio, and colleagues studied a group of men who were assessed for ED and subsequent cardiovascular disease over the course of 7 years. The study included men aged 55 years or older who were randomized to the placebo group (n = 9,457) in the Prostate Cancer Prevention Trial at 221 U.S. centers. Participants were evaluated every 3 months for cardiovascular disease and erectile dysfunction between 1994 and 2003. In analysis, factors at study entry taken into account included age, body mass index, blood pressure, serum lipids, diabetes, family history of heart attack, race, smoking history, current use of antihypertensive medication, physical activity, and quality of life.

Of the 9,457 men randomized to placebo, 8,063 (85 percent) had no cardiovascular disease at study entry; of these men, 3,816 (47 percent) had erectile dysfunction at study entry. Among the 4,247 men without erectile dysfunction at study entry, 2,420 men (57 percent) reported incident erectile dysfunction after 5 years. After adjustment, incident erectile dysfunction was associated with a 25 percent increased risk for subsequent cardiovascular events during study follow-up. For men with either incident or prevalent erectile dysfunction, the increased risk was 45 percent.

“Our analysis of men in the placebo group of this study demonstrates the substantial association between incident as well as prevalent erectile dysfunction and subsequent cardiovascular disease, including angina, myocardial infarction, stroke, and transient ischemic attack,” the authors write.

“The implications of this study are substantial. With the availability of effective pharmacotherapy, an increasing number of men are seeking care for erectile dysfunction. It is estimated that more than 600,000 men aged 40 to 69 years in the United States develop erectile dysfunction annually. Our data suggest that the older men in this group have about a 2-fold greater risk of cardiovascular disease than [younger] men without erectile dysfunction. With 70 percent to 89 percent of sudden cardiac deaths occurring in men and with many men not having regular physical examinations, this analysis suggests that the initial presentation of a man with erectile dysfunction should prompt the evaluating physician to screen for standard cardiovascular risk factors and, as appropriate, initiate cardioprotective interventions,” they write.

“Our data provide the first evidence, to our knowledge, of a strong association between erectile dysfunction and subsequent development of clinical cardiovascular events. Acknowledging this association over a 5-year period and the high prevalence of vasculogenic/atherogenic etiologies in men of this age, the presenting symptom of erectile dysfunction should prompt an assessment of cardiovascular risk factors and vigorous interventions as appropriate. While a full cardiovascular evaluation is not necessary in response to findings of erectile dysfunction in asymptomatic patients, such findings should prompt diligent observation of at-risk men and reinforces the need for intervention for cardiovascular risk factors,” the researchers conclude.

Erectile Dysfunction and Heart Disease Linked to Increased Risk of Death

October 29th, 2010 by dred55

Erectile dysfunction (ED) is associated with atherosclerosis and heart disease. A new study published online in the March 15th issue of the journal Circulation reports men with ED and heart disease are twice as likely as men with only heart disease to suffer death from any cause and twice as likely to have a heart attack. cialis5

The German researchers, lead by Dr. Michael Bohm, evaluated the collected data on 1549 patients with heart disease who took part in two trials: ONTARGET or TRANSCEND. In the ONTARGET study, patients were randomly assigned to receive ramipril (400), telmisartan (395), or the combination of the two drugs (381). In the TRANSCEND study, patients were randomly assigned to receive telmisartan (171) or a placebo (202).

All patients had an ED evaluation at baseline, at 2-year follow-up, and at the penultimate visit before closeout. They were classified as having mild, mild-to-moderate, moderate or severe erectile dysfunction. In both trials, in addition to cardiovascular disease, 55 percent of the men also had erectile dysfunction.

The researchers found men suffering from erectile dysfunction were more likely to have high blood pressure, stroke, diabetes and lower urinary tract surgery, compared to men without erectile dysfunction.

The researchers found the study medications did not influence the course or development of ED, but the presence of ED was found to be predictive of the risk of death.

Men with ED were found to be 1.84 times as likely to die from any cause as men without ED (hazard ratio [HR] 1.84). Separated out, the risk of death from a cardiovascular death was 1.94 times as high. The risk of a stoke was 1.1 times as high. The risk of being hospitalized for heart failure was 1.2 times as high.

Erectile dysfunction is linked to the endothelial dysfunction (problems with the cells that line the blood vessels) that occurs in atherosclerosis and the vascular disturbances such as the build-up of plaque that happens before heart attack and stroke, the study authors explained.

If a man has Erectile Dysfunction, but has not been diagnosed with heart disease, he and his doctor need to take another look. ED is a risk factor for cardiovascular disease just as high blood pressure and cholesterol are.

Health Canada Warns Against Ju Wang Erectile Dysfunction Treatment

October 27th, 2010 by dred55

Health Canada is advising consumers not to use Dr. Life and Chong Cao Ju Wang due to concerns about possible side-effects.

Dr. Life and Chong Cao Ju Wang are promoted for the treatment of erectile dysfunction.

Reason for Warning

The Hong Kong Department of Health warned consumers not to buy or use Dr. Life or Chong Cao Ju Wang because they were found to contain undeclared pharmaceutical ingredients. Dr. Life was found to contain an unauthorised substance with a structure similar to tadalafil (aminotadalafil) while Chong Cao Ju Wang was found to contain sildenafil.

Tadalafil and sildenafil are prescription drugs used in the treatment of erectile dysfunction, and should only be used under the supervision of a health care practitioner.

Possible Side-Effects

Unsupervised use of tadalafil or sildenafil by patients with heart disease can result in serious cardiovascular side-effects such as sudden cardiac death, heart attack, stroke, hypertension, chest pain and abnormal heartbeat. Additionally, use of tadalafil or sildenafil may be associated with other side-effects including temporary vision loss, seizure, prolonged erection, headache, flushing, nasal congestion and abdominal pain. Products containing tadalafil or sildenafil should not be used by individuals taking any type of nitrate drug (e.g., nitroglycerine) due to the risk of developing potentially life-threatening low blood pressure.

Consumers Warned Not To Use Any Unauthorized Products Promoted To Enhance Sexual Performance

October 25th, 2010 by dred55

Health Canada is warning consumers not to use Desire, an unauthorized product promoted to enhance male sexual performance as this product may pose serious health risks in certain patients. Lot 0070263 of the product was found to contain the prescription drug phentolamine, which is not indicated on the label. Phentolamine is currently authorized for intravenous use in the prevention and control of high blood pressure in patients with adrenal tumours, and should only be used under the supervision of a health care professional. Patients with pre-existing medical conditions, including those with heart problems, those taking heart or blood pressure medications, or those at risk for strokes, may be at an increased risk of serious health effects.

Use of phentolamine by patients with heart disease can potentially result in serious cardiac side-effects such as low blood pressure, chest pain and abnormal heartbeat. Other side-effects may include dizziness, loss of consciousness, prolonged erection, headache, flushing, nasal congestion, indigestion and abdominal pain.

Desire is labelled as manufactured by Desire LLC, and distributed by StarChem Labs, of Farmingdale, New York. The product may be available at retail outlets across Canada, and over the Internet.

Health Canada advises retailers to remove Desire from their shelves, and consumers should return the product to the place of purchase. Health Canada is taking steps to confirm that the product has been removed from the Canadian market. Health Canada has not received any reports of adverse reactions associated with this product. Canadians who have used Desire LLC and are concerned about their health should consult with a health care professional.

Health Canada advises consumers not to use Desire or any other unauthorized products promoted to increase sexual performance that are advertised as “all natural”, as such products may contain undeclared prescription drugs that may pose serious risks to health. Consumers who are concerned about erectile dysfunction should consult with their health care professional to discuss appropriate and authorized treatments.

Drugs and natural health products that are authorized for sale in Canada have an eight-digit Drug Identification Number (DIN), a Natural Product Number (NPN) or a Drug Identification Number for Homeopathic Medicine (DIN-HM) on the label.

Erectile Dysfunction Drugs Linked to Higher Rates of HIV, Chlamydia

October 12th, 2010 by dred55

Researchers have found a link between men using drugs to treat erectile dysfunction (ED) and higher rates of the sexually transmitted diseases HIV and Chlamydia. Men who use drugs like Viagra, Cialis and Levitra may also be engaging in high risk behavior suggest the scientists. Findings from a study of more than 1.4 million men revealed two to three times the rate of sexually transmitted disease among men who request drugs for erectile dysfunction, with HIV being the most prevalent STD.

Study author Dr. Anupam B. Jena, an internal medicine resident at Massachusetts General says, “Our findings suggest is that just by virtue of asking for an ED drug, these men are identifying themselves as being at two to three times higher risk of STDs.” The authors suggest that physicians counsel men taking drugs for erectile dysfunction about safe sex practices. The study did not take into account sexual preferences.

The researchers also say most physicians don’t counsel older men who take drugs for erectile dysfunction about STD risk and safe sex, reserving those talks for younger men. The authors obtained the information from insurance records examined between 1997 and 2006 that included approximately 34,000 male beneficiaries.

After the first prescription for erectile dysfunction was filled, the men studied were found to have a two to three time higher rate of sexually transmitted disease compared to men over 40 not using ED drugs. The most common STD among men using ED drugs was HIV, followed by Chlamydia.

One of the reasons HIV was the most prevalent disease linked to men using ED drugs may because symptoms of HIV drive them to their healthcare provider. Dr. Jena explains, “The symptoms that are associated with a primary HIV infection are the kinds of things that make men more likely to show up to a doctor, rather than go to a free clinic where they know they can get tested for an STD anonymously.”

Dr. Peter Leone, a professor of medicine at the University of North Carolina and board chair of the National Coalition of STD Directors says the findings are no surprise. Doctors have suspected it’s not just men with erectile dysfunction taking the likes of Viagra, Cialis and Levitra. Dr. Leone says, “… they’re also men in high risk groups who take it to enhance sexual activity.”

He suggests that physicians should screen men who use erectile dysfunction drugs for sexually transmitted diseases, adding that repeated follow up for STD testing is also important unless men are using condoms or in a monogamous relationship. He also says it’s not erectile dysfunction drugs leading to higher rates of the STD’s HIV and Chlamydia – “it’s really the other way around”. The study concluded, “Men who use ED drugs have higher rates of STDs, particularly HIV infection, both in the year before and after use of these drugs.”

Back pain treatment could solve erection problems

October 8th, 2010 by dred55

Men who experience back pain and lower spine problems could also experience problems with erections. Irwin Goldstein, M.D., medical director of Alvarado Hospital’s Sexual Medicine Program—the first hospital-based sexual medicine program in the U.S.—and editor-in-chief of The Journal of Sexual Medicine, recently discovered that treating one patient’s back pain also cured his erection problems.

The patient had experienced a car accident, and complained of leg numbness, back pain and erectile dysfunction. “After completing the initial workup, we determined the problem was the patient’s pelvic floor muscles,” Dr. Goldstein said. “We referred him to one of the hospital’s physical therapist who had advanced training in pelvic floor rehabilitation.” Treating the back pain resulted in improvement in erectile dysfunction.

Erectile dysfunction drugs may not always be needed. Back pain treatment could improve erectile dysfunction long-term. Back injuries can cause trapping of blood. Men with back pain may be experiencing blood flow difficulties in the pelvis as the cause of erection problems. According to Dr. Goldstein, pelvic muscles can become weak and spasm from back injuries, resulting in decreased sexual function from limited blood flow to the penis when muscles spasm.

Muscle energy, core and lumbar strengthening exercises to align the pelvis and relax the pelvic floor muscles, performed by Physical therapist and pelvic floor specialist Kerri Krebs, facilitated recovery. Following treatment, erectile function and leg numbness improved for the patient, who had seen several other physicians and also had been prescribed erectile dysfunction medication.

Orthopedic spine specialist Ramin Raiszadeh, M.D warns however that men with back or pelvic pain, or who experience urinary incontinence need to see a specialist as soon as possible. Erection problems can be caused by …”other medical conditions, including cardiovascular disease, diabetes, infection, inflammation and tumors can cause these symptoms as well.”

Other approaches to treat erectile dysfunction linked to back pain and injury include Yoga, acupuncture, steroid injections, or massage. Disc herniation, muscle spasm from inactivity and weakness, spinal stenosis, and traumatic back injuries can also cause erection difficulties. Keeping your back in shape, and getting treatment for back pain could lead to improved sexual function and less difficulty with erections, and should be explored after more serious causes of erectile dysfunction are ruled out. “If the sexual problem persists, the patient should see a sexual medicine specialist,” says Dr. Goldstein.